Endocrine Abstracts

Members of the TGF-β superfamily of ligands signal through a combination of Type I and Type II receptors. Type I and Type II receptors have been related to various human diseases including developmental malformation, cancers and endocrine disorders. However, little is known about the function of ALK7, a Type I receptor expressed in prenatal and adult CNS and various endocrine tissues. We have generated a mice lacking ALK7, which are viable and fertile but display metaboli...